Hepatoprotective and Antidiabetic Effect of Methanol Extract of Caralluma Fimbriata in Streptatozocin Induced Diabetic Albino Rats

Objective: Effect of methanol extract of Caralluma fimbriata (MCF) on streptatozocin (STZ) 50 mg/kg b.w. induced diabetic rats was studied. Methods: Oral administration of methanol extract of Caralluma fimbriata (MCF) to diabetic rats at a dose of 100 and 200 mg/kg body weight resulted in a significant reduction in blood glucose in STZ induced diabetic rats at different treatment period (0thday, 7thday, 14th day and 21st day). Results: The MCF treated diabetic rats were significantly recovered from hepatotoxicity, diabetic and renal toxicity by analyzing the factors such as, body weight, Glycosylated hemoglobin, Plasma insulin, Total protein, SGOT, SGPT and ALP. Further the histopathology results of MCF treated rats also confirmed the significant recovery of liver and kidney destruction. Conclusion: Our study reveals the therapeutic effect of MCF for diabetes and its related complications.